Mood Is Your Worst Enemy. 8 Ways To Defeat It
Psychedelic Definition, Meaning & Synonyms This transcript was stably transfected into HEK-293 cells to generate what the authors designated as an SB1 cell population. Serotonin, dopamine, DOI, and clozapine all produced robust internalization, whereas the 5-HT2A antagonist ketanserin did not. PKC activation by a phorbol ester was sufficient to cause endocytosis in the absence of any agonist. In an earlier study, the authors had shown that PKC activation was required for internalization by 5-HT, but not by dopamine. Sphingosine, an inhibitor of PKC activation, almost completely prevented 5-HT– or DOI–mediated receptor internalization but did not affect dopamine-mediated internalization. Patch-clamp recordings in HEK-293 cells stably expressing the human cardiac Na+ channel hNav1.5 showed that application of 100 μM DMT inhibited the INa by 62%. The authors conclude on the basis of this and other data in their report that DMT may serve as an endogenous sigma receptor ligand. Much...